Hadeel A. Ibrahim, Mohammed O. Mohammed, Hawa A.R. Al-Dhahir


Background: Helicobacter pylori (H. pylori) infection stimulates the production of proinflammatory cytokines associated with the development of atherosclerosis. Levels of circulating interleukin-18 (IL-18) have been positively correlated with carotid intima-media thickness (CIMT) and coronary plaque area and have been identified as important predictors of coronary events and cardiovascular mortality. This study aimed to examine the relationship between serum IL-18, carotid intima thickness and H. pylori-IgG antibody as a sign of H. pylori infection in dyspeptic patients.

Methods: This cross sectional- case control study was conducted in Kurdistan Teaching center for Gastroenterology and Hepatology (KCGH) in Sulaimani city from January 2014 to March 2015. One hundred dyspeptic patients with positive H. pylori infection and 100 apparently healthy asymptomatic volunteers with negative H. pylori tests were enrolled in this study. Sera were tested for H. pylori IgG & IgA antibodies at Sulaimani Central lab., using ELISA tests. Interleukin 18 (IL-18) was measured based on immunoenzymometric assay. All participants were evaluated for both internal carotid (IC) and common carotid (CC) arteries thickness by using high resolution grey-scale Doppler ultrasonography.

Results: A significant difference (P<0.01) was found between patients and controls in the mean serum IL-18. A significant correlation between H. pylori IgG level and IL-18 was found (p < 0.01), but not with H. pylori IgA level. A significant correlation was found between IL 18 level and ICA, CCA thickness in H. pylori positive patients (p < 0.01).

ConclusionH. pylori infection was significantly associated with higher serum  IL-18. There was significant correlation between IL-18 and Carotid intima- media thickness.


Keywords: H. pylori, IL-18, Carotid Thickness, Sulaimani.


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